jackson et al 2018
/ 2 min read
Table of Contents
References Atlan et al., 2018 a lot
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(09/10/2023, 09:22:08 )
CLA future research: methods partially already implemented
“a wealth of new molecular tools have provided methods to selectively manipulate” (Jackson, 2018, p. R937)
[[Atlan et al., 2018]]
“Atlan et al. [7] have exploited these new techniques to identify, label, and manipulate claustrum neural activity” (Jackson, 2018, p. R937)
CLA attention: attention through filtering out distracting sensory stimuli
“Their results suggest that the claustrum functions to filter out distracting stimuli in the sensory environment and thus may serve to focus their attention on the task at hand” (Jackson, 2018, p. R937)
CLA connections to Anterior Cingulate Cortex (ACC) important for CLA attention
“In the mouse, the claustrum connects most prominently with an area of the prefrontal cortex termed the anterior cingulate cortex (ACC)” (Jackson, 2018, p. R937)
“As the ACC has an established role in attentional processing and short-term memory [10], it has been hypothesized that the claustrum may also participate in attentional processes” (Jackson, 2018, p. R937)
CLA attention might be important for more difficult multisensory tasks
“This exciting result suggests that the claustrum may play a role in ignoring or ‘tuning out’ irrelevant sensory stimuli. Moreover, the claustrum may only be recruited in more difficult multisensory tasks.” (Jackson, 2018, p. R937)
“Similar to the two alternative-forced-choice task, claustrum suppression did not affect the pup retrieval by mothers. But when the auditory distractor was added, mothers required nearly 400% more time to retrieve their pups” (Jackson, 2018, p. R938)
CLA auditory: “optogenetic activation of the claustrum decreased auditory cortex activity to pure tones”
(Jackson, 2018, p. R938); Atlan et al., 2018
“the thin elongated geometry of the claustrum has made it difficult to record its activity and perform classic pharmacological manipulations or electrolytic lesions without inevitably perturbing neighboring brain regions” (Jackson, 2018, p. R937)